How It Works
Discover how Micotil works for you in your operation and for your schedule.
Why Micotil Works
Micotil is a proven, long-lasting BRD treatment that offers flexible, cost-effective dosing for both metaphylaxis and individual pull-and-treat therapy. Explore below how it impacts the lungs, respiratory tract and immune cells in cattle after just one dose.
Alveolar macrophages, the primary defence mechanism in the lower respiratory tract. engulf pathogens, kill and digest them. * They recruit neutrophils through cytokine release.
Neutrophils quickly move from the blood stream in response to bacterial invasion to the site of the infection. Like macrophages, they also kill bacteria by engulfing and digesting them. *
Micotil concentrates in the alveolar macrophages and neutrophils and is carried straight to the site of BRD infection where it is needed most.*
A Timeline Of Micotil
REACHES CATTLE'S LUNGS FAST*
- Micotil reaches cattle’s lungs in 1 hour1,2
- Micotil reaches consolidated lungs in 2 hours1,2
FIGURE 1.
EFFECTIVE CONCENTRATIONS THROUGHOUT THE RESPIRATORY TRACT*
- Micotil stays at effective levels for 3 to 4 days through the respiratory tract, including pneumonic lung tissue,1,2 tracheal mucosa3 and where the respiratory infectious process begins - the tonsils3
FIGURE 2.
LONG-LASTING LEVELS*
- Micotil maintains levels in alveolar macrophages3 and neutrophils4 for up to 10 days
- These immune cells deliver Micotil when and where it's needed most - at the site of the infection
FIGURE 3.
aLung tissue from cattle with acute pneumonia.
b95% of the Mannheimia (Pasteurella) haemolytica isolates were inhibited by 3.12 µg/mL.
*Clinical significane of these data has not been demonstrated. Data based on 10 mg/kg of body weight( 1.5 mL/100 lbs) dosage level.
Get CertifiedGet Certified
Take the Micotil Safety Course today and become certified to purchase and administer Micotil.
Start NowIndication
Micotil® (tilmicosin injection) is indicated for the treatment of bovine respiratory disease (BRD) associated with Mannheimia haemolytica, Pasteurella multocida and Histophilus sommi, and for the control of respiratory disease in cattle at high risk of developing BRD associated with Mannheimia haemolytica.
Important safety information
Before using this product, it is important to read the entire product insert, including the boxed human warning. Caution: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Not for human use. Injection of this drug in humans has been associated with fatalities. Keep out of reach of children. Do not use in automatically powered syringes. Exercise extreme caution to avoid accidental self-injection. In case of human injection, consult a physician immediately and apply ice or cold pack to injection site while avoiding direct contact with skin. Avoid contact with eyes. Always use proper drug handling procedures to avoid accidental self-injection. Consult your veterinarian on the safe handling and use of all injectable products prior to administration. For use in cattle or sheep only. Inject subcutaneously. Injection of this antibiotic has shown to be fatal in swine and non-human primates, and may be fatal in horses and goats. Do not use in female dairy cattle 20 months of age or older. Use in lactating dairy cattle may cause milk residues. The following adverse reactions have been reported: in cattle: injection site swelling and inflammation, lameness, collapse, anaphylaxis/anaphylactoid reactions, decreased food and water consumption, and death. Micotil has a pre-slaughter withdrawal time of 42 days.
Get Certified
Micotil, Elanco and the diagonal bar logo are trademarks of Elanco or its affiliates. Other product names are trademarks of their respective owners.
©2020 Elanco and its affiliates. PM-US-20-0737(2)